From the Research
The best treatment for Ozempic (semaglutide) side effects focuses on managing the most common gastrointestinal symptoms, with the most recent and highest quality study 1 supporting the use of dietary changes and over-the-counter medications to alleviate these symptoms. To manage nausea and vomiting, patients can eat smaller, more frequent meals, avoid fatty or spicy foods, stay hydrated, and consider over-the-counter medications like Dramamine or Bonine. For constipation, increasing fiber intake gradually through fruits, vegetables, and whole grains, drinking plenty of water, exercising regularly, and trying over-the-counter stool softeners like docusate sodium (Colace) or fiber supplements like psyllium (Metamucil) can be beneficial. Diarrhea can be managed by following the BRAT diet (bananas, rice, applesauce, toast), staying hydrated with clear fluids, and considering loperamide (Imodium) if needed. Headaches can be treated with acetaminophen (Tylenol) or ibuprofen (Advil). Most side effects typically improve within 4-8 weeks as the body adjusts to the medication, as noted in studies 2, 3. If side effects are severe or persistent, the doctor might recommend slowing down the dose escalation schedule or temporarily reducing the dose, as suggested by research on semaglutide's effects 4, 5. These side effects occur because Ozempic slows gastric emptying and affects the central nervous system's regulation of nausea and appetite, which is also how it helps with weight loss and blood sugar control, as discussed in the context of its approval for weight loss 1.