From the Research
D-Chiro-Inositol (DCI) may be beneficial for infertility, particularly in women with polycystic ovary syndrome (PCOS), as it improves insulin sensitivity and regulates hormonal balance and ovulation. The most recent and highest quality study 1 suggests that DCI can induce ovulation in non-PCOS, non-insulin-resistant women, likely by modulating aromatase expression. Key points to consider when using DCI for infertility include:
- A typical dosage ranges from 600-1200 mg daily, often taken in divided doses with meals
- DCI should be used consistently for at least 3-6 months for best results
- DCI works by improving insulin sensitivity, which helps regulate hormonal balance and ovulation in women with insulin resistance
- DCI is often more effective when combined with Myo-inositol in a 40:1 ratio (Myo:DCI), as this mimics the body's natural ratio
- While generally considered safe with minimal side effects, it's essential to consult with a healthcare provider before starting DCI, especially if you're taking medications for diabetes or have other health conditions
- DCI supplements should be part of a comprehensive approach to fertility that includes a balanced diet, regular exercise, stress management, and appropriate medical care. Other studies 2, 3, 4, 5 also support the use of DCI for infertility, particularly in women with PCOS, but the most recent study 1 provides the strongest evidence for its effectiveness.