From the Research
Invega (paliperidone) is not typically associated with causing diabetes insipidus, and the most recent evidence suggests that it does not directly cause this condition. Diabetes insipidus is a rare condition characterized by excessive thirst and urination due to problems with antidiuretic hormone (ADH) regulation 1. While Invega, an atypical antipsychotic medication, has been linked to metabolic side effects including weight gain and type 2 diabetes mellitus, it does not directly cause diabetes insipidus. The metabolic concerns with Invega relate to insulin resistance and glucose metabolism, which are different mechanisms from those involved in diabetes insipidus.
Some key points to consider when evaluating the relationship between Invega and diabetes insipidus include:
- The diagnosis of diabetes insipidus involves differentiating between central diabetes insipidus, nephrogenic diabetes insipidus, and primary polydipsia 2, 3, 4
- Treatment of diabetes insipidus depends on the underlying aetiology and differs in central diabetes insipidus, nephrogenic diabetes insipidus, and primary polydipsia 3, 1
- Regular monitoring of metabolic parameters is recommended for patients taking antipsychotic medications like Invega, including blood glucose levels, lipid profiles, and weight 1
If you're experiencing symptoms like extreme thirst and frequent urination while taking Invega, these could be signs of other conditions, including type 2 diabetes mellitus or medication side effects, and should be evaluated by a healthcare provider. The most important consideration is to prioritize the patient's morbidity, mortality, and quality of life, and to evaluate any symptoms or concerns in the context of their overall health and medication regimen.