What is the diagnosis for a fluid-filled cyst on the underside of the glans penis?

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Differential Diagnosis for Fluid Filled Cyst on Underside of Penis Head

  • Single most likely diagnosis
    • Pearly Penile Papule: A benign condition characterized by small, fluid-filled cysts or papules on the penis, often found on the corona or underside of the penis head. This condition is common and usually requires no treatment.
  • Other Likely diagnoses
    • Epidermoid Cyst: A benign cyst that can occur on the penis, filled with a cheesy material or fluid, often resulting from a blocked oil gland. These cysts are generally harmless but may become inflamed or infected.
    • Fordyce Spots: Small, yellowish or white bumps on the penis that can sometimes appear as fluid-filled cysts, caused by ectopic sebaceous glands. They are benign and typically do not require treatment.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Penile Cancer: Although rare, any unusual growth or lesion on the penis should be evaluated for the possibility of cancer. Early detection is crucial for effective treatment.
    • Genital Herpes: Caused by the herpes simplex virus, this condition can lead to painful blisters or sores that might initially be mistaken for fluid-filled cysts. It's a significant diagnosis due to its infectious nature and potential for complications.
  • Rare diagnoses
    • Urethral Diverticulum: An outpouching of the urethral wall that can present as a fluid-filled cyst, more commonly found in women but can occur in men. It may cause symptoms like urinary incontinence or recurrent infections.
    • Müllerian Duct Cyst: A rare congenital anomaly that can present as a cystic structure on the penis, resulting from remnants of the Müllerian ducts. These cysts are usually benign but can become infected or cause urinary symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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