From the Guidelines
Protopic (tacrolimus ointment) should be prescribed in a strength of 0.03% for children 2-15 years old and 0.1% for patients 16 years and older, as supported by the most recent evidence from 2024 1. When considering the treatment of atopic conjunctivitis, it is essential to note that Protopic has been used off-label for ophthalmic disease. The recommended dosage is based on the patient's age, with 0.03% used for children 2-15 years old and 0.1% used for patients 16 years and older 1. Some key points to consider when prescribing Protopic include:
- Applying the ointment thinly to affected areas, typically twice daily
- Continuing treatment for one week after symptoms clear
- Reevaluating the patient if no improvement occurs within two weeks
- Informing patients about potential complications, such as increased susceptibility to herpes simplex keratitis 1
- Minimizing sun exposure during treatment due to potential increased sensitivity to UV light It is crucial to prioritize the patient's safety and adjust the treatment plan accordingly, taking into account the potential risks and benefits of Protopic, as well as alternative treatment options, such as topical corticosteroids and antihistamines 1.
From the Research
Protopic Dose Information
- The typical dose of Protopic (tacrolimus ointment) is 0.03% or 0.1% applied twice daily to affected areas 2.
- Studies have shown that both 0.03% and 0.1% concentrations are effective in treating atopic dermatitis, with significant improvements in signs of atopic dermatitis such as erythema, edema, excoriation, oozing, scaling, and lichenification 2, 3.
- The choice of concentration may depend on the severity of the condition and the patient's response to treatment, with 0.1% being more effective than 0.03% in some cases 3.
Application and Administration
- Protopic ointment should be applied twice daily to affected areas, up to a maximum of 12 weeks 2.
- The ointment can be used on the head and neck, as well as other areas of the body, with similar efficacy and safety profiles 2.
- Patients should be instructed to wash their hands after applying the ointment and to avoid applying it to broken or irritated skin 4.
Safety and Tolerability
- Protopic ointment is generally well-tolerated, with common adverse events including pruritus, skin burning, erythema, infection, and skin tingling 2, 4.
- The incidence of application site adverse events decreases rapidly during the first few days of treatment 2.
- Long-term safety data have shown that Protopic ointment is safe and effective for up to 6 months of treatment 4.