From the FDA Drug Label
L-METHYLFOLATE CALCIUM Tablets is a medical food for use under medical supervision and direction L-METHYLFOLATE CALCIUM Tablets is a medical food dispensed by prescription. Use under medical supervision. Use under medical/physician supervision.
To take Deplin (L-methylfolate), it is essential to follow these key steps:
- Use Deplin under medical supervision.
- Deplin is a medical food dispensed by prescription.
- Follow the guidance of your physician for proper use. There is no specific information on the dosage frequency, so it is crucial to consult your doctor for personalized instructions 1, 1, 1.
From the Research
Deplin should be taken once daily with or without food, as directed by your healthcare provider, with a typical dose of 15 mg per day, as this dose has been shown to be the most effective in recent studies 2. The medication should be swallowed whole with water, without crushing, chewing, or splitting, to maintain its efficacy. It's essential to take Deplin at the same time each day to maintain consistent levels in the body. If a dose is missed, it should be taken as soon as remembered, but skipped if it's almost time for the next dose. Deplin is a medical food containing L-methylfolate, which can cross the blood-brain barrier and help produce neurotransmitters like serotonin, dopamine, and norepinephrine. It's often prescribed for people with depression who have genetic variations affecting folate metabolism or as an adjunct to antidepressant medications. Some key points to consider when taking Deplin include:
- Storing the medication at room temperature away from moisture and heat
- Continuing to take Deplin for the full prescribed duration, even if symptoms improve
- Being aware of the potential benefits of L-methylfolate supplementation on sleep for patients with reduced methylenetetrahydrofolate reductase activity 3
- Understanding the connection between folate and depression, including the role of L-methylfolate in monoamine neurotransmitter biosynthesis 4