What sexually transmitted infection (STI) testing is recommended for a 25-year-old male who has sex with women (MSW)?

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Last updated: May 16, 2025View editorial policy

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From the Research

For a 25-year-old heterosexual male, I recommend comprehensive STI testing including gonorrhea and chlamydia (urine test), HIV, syphilis, and hepatitis B and C (blood tests) annually if sexually active with multiple partners, after unprotected sex with a new partner, or if experiencing symptoms like penile discharge, burning urination, genital sores, or pain. This recommendation is based on the most recent guidelines from the Centers for Disease Control and Prevention, as outlined in the 2022 study published in the American Family Physician 1.

Importance of Regular Testing

Regular testing is crucial because many STIs are asymptomatic but can cause serious complications if left untreated, including fertility issues and increased risk of other infections 2. The 2022 study published in JAMA highlights the importance of screening, contact tracing of sexual partners, and promoting effective barrier contraception as effective STI prevention interventions 2.

Testing Frequency

For those with multiple partners, testing every 3-6 months is advisable. Most tests can detect infections within 2-3 weeks of exposure, though HIV may require testing at both 4 weeks and 3 months for accuracy 2. Many clinics offer confidential testing, and home test kits are available for some STIs.

Prevention

Consistent condom use significantly reduces transmission risk but doesn't eliminate it completely for infections spread through skin contact. It is essential to note that while the 1999 study published in the American Family Physician provides valuable information on treatment options for various STIs, the most recent guidelines and recommendations should be followed for testing and treatment 3.

Key Considerations

When considering STI testing, it is essential to prioritize the most recent and highest-quality studies, such as the 2022 study published in the American Family Physician 1 and the 2022 study published in JAMA 2, to ensure that recommendations are based on the latest evidence and guidelines.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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