From the Guidelines
10 ml of diphenhydramine syrup contains 12.5 mg of diphenhydramine, which is equivalent to 0.0125 grams of the active ingredient. To determine the diphenhydramine content in grams, we need to look at the concentration of the syrup, which is 12.5 mg/mL, as stated in the study 1.
Key Points to Consider:
- The concentration of diphenhydramine in the syrup is 12.5 mg/mL, which is equivalent to 0.0125 grams/mL.
- The total amount of diphenhydramine in 10 mL of syrup can be calculated by multiplying the concentration by the volume: 0.0125 grams/mL x 10 mL = 0.125 grams.
- It's essential to note that the study 1 provides information on the dosage forms and concentrations of various antihistamines, including diphenhydramine.
Usage Guidelines:
- Adults and children 12 years and over: Take 25-50 mg (10-20 ml) every 4-6 hours as needed
- Children 6-11 years: Take 12.5-25 mg (5-10 ml) every 4-6 hours as needed
- Do not exceed 300 mg (120 ml) in 24 hours for adults or 150 mg (60 ml) for children Always use the measuring device provided with the medication for accurate dosing. Diphenhydramine can cause drowsiness, so avoid driving or operating machinery after taking it. The syrup form allows for easier dosing adjustments compared to tablets, especially for children or those who have difficulty swallowing pills.
From the FDA Drug Label
Active ingredient per 10 mL (1 Unit Dose) Diphenhydramine HCl 25 mg Each 10 mL of Diphenhydramine HCl Oral Solution contains Diphenhydramine HCl 25 mg The diphenhydramine content in 10 ml of diphenhydramine syrup is 25 milligrams. To convert milligrams to grams, we divide by 1000, so the diphenhydramine content is 0.025 grams 2 2.
From the Research
Diphenhydramine Content in Syrup
- The diphenhydramine content in grams in 10 ml of diphenhydramine syrup is not directly stated in the provided studies 3, 4, 5, 6, 7.
- However, study 6 mentions that the linearity range for concentrations of diphenhydramine was found to be 12.5-150 microg/mL, which can be used to estimate the diphenhydramine content in 10 ml of syrup.
- Assuming a concentration of 12.5 microg/mL, the diphenhydramine content in 10 ml of syrup would be approximately 0.125 mg or 0.000125 g.
- Study 4 also mentions that the calibration graph is linear over the concentration ranges of 5-21 and 75-188 microgm l(-1), but it does not provide a direct conversion to grams.
- Study 5 mentions that the absorption spectra of DPH in the range of 5.0-40.0 μg/mL were recorded, but it does not provide a direct conversion to grams in 10 ml of syrup.
- Therefore, based on the available information, it is not possible to provide an exact answer to the question, but study 6 provides a rough estimate of the diphenhydramine content in 10 ml of syrup 6.
Concentration of Diphenhydramine
- The concentration of diphenhydramine in syrup can vary depending on the formulation and preparation method 4, 5, 6.
- Study 4 mentions that the method is applied to assay for capsule and syrup samples, but it does not provide a specific concentration for the syrup.
- Study 5 mentions that the quantitative estimation of the DPH content of a reconstitutable syrup formulation is not possible by the direct absorbance measurement, but it does not provide a specific concentration for the syrup.
- Study 6 mentions that the proposed method was validated according to the ICH guidelines with respect to linearity, limit of detection, limit of quantification, accuracy, precision, recovery, and robustness, but it does not provide a specific concentration for the syrup 6.
Limitations
- The provided studies do not provide a direct answer to the question of the diphenhydramine content in grams in 10 ml of diphenhydramine syrup 3, 4, 5, 6, 7.
- The studies provide information on the concentration of diphenhydramine in microg/mL, but they do not provide a direct conversion to grams in 10 ml of syrup.
- Therefore, the answer to the question can only be estimated based on the available information 6.