What could cause an inflamed ear canal with a clean tympanic (eardrum) membrane?

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Last updated: May 17, 2025 • View editorial policy

Differential Diagnosis for Inflamed Ear Canal with Clean Tympanic Membrane

  • Single most likely diagnosis: + Otitis externa: This is the most likely diagnosis given the inflamed ear canal and clean tympanic membrane. Otitis externa, also known as swimmer's ear, is an infection of the outer ear canal that can cause inflammation, redness, and discomfort.
  • Other Likely diagnoses: + Eczema or dermatitis of the ear canal: Skin conditions like eczema or dermatitis can cause inflammation and irritation in the ear canal, leading to similar symptoms. + Allergic reaction: An allergic reaction to ear drops, jewelry, or other substances can cause inflammation and itching in the ear canal. + Irritation from earwax removal or ear cleaning: Aggressive ear cleaning or earwax removal can irritate the ear canal and cause inflammation.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.): + Malignant otitis externa: This is a rare but serious infection that can occur in people with compromised immune systems, such as those with diabetes or HIV/AIDS. It can cause severe inflammation and destruction of the ear canal and surrounding tissues. + Necrotizing otitis externa: This is a rare and serious condition that can cause destruction of the ear canal and surrounding tissues, leading to severe complications if left untreated.
  • Rare diagnoses: + Relapsing polychondritis: This is a rare autoimmune disorder that can cause inflammation and destruction of cartilage in the ear and other parts of the body. + Sarcoidosis: This is a rare condition that can cause inflammation and granulomas in various parts of the body, including the ear canal. + Granulomatosis with polyangiitis (GPA): This is a rare autoimmune disorder that can cause inflammation and destruction of blood vessels and tissues in the ear and other parts of the body.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.