What are the effects of Garcinia cambogia (Garcinia gummi-gutta)?

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Last updated: May 17, 2025View editorial policy

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From the Research

Garcinia cambogia should be avoided due to the risk of liver damage and other potential side effects, as evidenced by recent studies 1, 2. The active ingredient in Garcinia cambogia is hydroxycitric acid (HCA), which is claimed to block an enzyme called citrate lyase that your body uses to make fat and may also raise serotonin levels to suppress appetite. However, the effectiveness of Garcinia cambogia for weight loss is limited and mixed, with most studies showing minimal effects compared to placebo 2.

Potential Risks and Side Effects

  • Liver damage: There have been reports of liver damage and fulminant hepatic failure associated with Garcinia cambogia use 3, 4, 1.
  • Digestive issues: Garcinia cambogia may cause digestive issues such as diarrhea, stomach cramps, and nausea.
  • Headaches: Some people may experience headaches when taking Garcinia cambogia.
  • Interactions with medications: Garcinia cambogia may interact with certain medications, such as diabetes medications, statins, blood thinners, and psychiatric medications.

Recommendation

Given the potential risks and limited effectiveness, it is recommended to avoid using Garcinia cambogia as a weight loss supplement 2. Instead, individuals can focus on evidence-based weight loss methods, such as a healthy diet and regular exercise. If considering any supplement regimen, it is essential to consult with a healthcare provider, especially if you have existing health conditions.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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