From the Guidelines
DHEA supplementation in men may offer several potential benefits, including modest improvements in sexual function, though it should be approached with caution, as the most recent and highest quality study suggests its use is uncertain and should be considered on a case-by-case basis 1. The benefits of DHEA supplementation in men are still being researched, and the current evidence is not conclusive. However, some studies suggest that DHEA may have a positive effect on sexual function, particularly in men with below-normal DHEA levels.
- Potential benefits of DHEA supplementation include:
- Modest improvements in sexual function
- Slight increases in muscle mass when combined with resistance training
- Possible enhancement of mood and energy levels
- Potential support for immune function
- However, the use of DHEA supplementation is not without risks, and men should be cautious when considering its use.
- Side effects may include acne, hair loss, and hormonal imbalances
- DHEA may interact with certain medications or affect prostate health
- The most recent study suggests that the use of vaginal DHEA in survivors of hormonally mediated cancers should be approached with caution, as it may increase levels of circulating androgens, which have the potential to impact AI activity 1. It is essential to note that the benefits of DHEA supplementation are generally modest and primarily relevant for men with below-normal DHEA levels, typically those over 40. Before starting DHEA, men should have their hormone levels tested by a healthcare provider, as supplementation is unnecessary and potentially harmful for those with normal levels.
- The most recent and highest quality study suggests that DHEA should be used with caution in survivors receiving AI therapy, and its safety has not been firmly established in survivors of estrogen-dependent cancers 1. In conclusion, while DHEA supplementation may offer some benefits for men, its use should be approached with caution, and men should consult with their healthcare provider to determine if supplementation is necessary and safe for their individual situation.
From the FDA Drug Label
INDICATIONS: Temporarily supports the body to rebalance Adrenal and DHEA output. Symptoms of imbalanced Adrenal and DHEA may include: low energy, depression, anxiety, dry eyes, skin, and hair, loss of head hair. The benefits of DHEA supplementation in men may include:
- Rebalancing Adrenal and DHEA output
- Alleviating symptoms such as:
- Low energy
- Depression
- Anxiety
- Dry eyes, skin, and hair
- Loss of head hair 2
From the Research
Benefits of DHEA Supplementation in Men
- Improved quality of life, body composition, bone health, and metabolic markers in patients with adrenal insufficiency 3
- Enhanced well-being, with 67% of men reporting improved well-being on DHEA compared to placebo in one study 4
- Improved physical and psychological well-being, muscle strength, and bone density, as well as reduced body fat and age-related skin atrophy 5
- Improved sexual satisfaction and fertility in men 5, 6
- Potential immunomodulatory effects, including increased monocytes, T cells, and natural killer cells 5
- Possible cardiovascular benefits, including reduced total cholesterol and improved insulin sensitivity 5
Specific Benefits in Aging Men
- Improved cardiovascular system, body composition, bone mineral density, skin, central nervous system, and immune system 6
- Delayed and corrected age-related disorders, such as sexual dysfunction and decreased muscle mass 6
- Potential to improve cognitive function, although more research is needed to confirm this benefit 4
Important Considerations
- DHEA supplementation should be individualized, with dosing adjusted to maintain serum concentrations in the physiological range of young males 6
- More research is needed to fully understand the benefits and risks of DHEA supplementation in men, particularly in terms of optimal dosing and duration of treatment 3, 4, 5