From the Guidelines
The recommended daily dose of Cialis (tadalafil) for erectile dysfunction is typically 2.5 mg or 5 mg taken once daily at approximately the same time each day, regardless of when sexual activity is anticipated. This daily dosing regimen allows for continuous availability of the medication in the bloodstream, enabling spontaneous sexual activity. Patients should start with 2.5 mg and may increase to 5 mg based on effectiveness and tolerability, as supported by a study from 1. For those with kidney or liver impairment, a lower dose of 2.5 mg may be more appropriate. Daily Cialis works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which increases blood flow to the penis during sexual stimulation. Unlike as-needed dosing (which can be 10-20 mg taken before sexual activity), daily Cialis maintains a steady level in the body, potentially reducing side effects like headache, indigestion, and muscle aches. However, it's worth noting that a more recent study from 1 mentions a different dosing of 40mg daily orally for tadalafil, but this is in the context of pulmonary hypertension-specific therapies, not erectile dysfunction. Therefore, the dosing for erectile dysfunction should still follow the guidelines provided in 1 and 1, which recommend 2.5 mg or 5 mg daily. Patients should not take more than one dose per day and should consult their healthcare provider before starting this medication, especially if they have cardiovascular issues or take nitrates, as these combinations can cause dangerous drops in blood pressure, as mentioned in 1.
Some key points to consider when prescribing daily Cialis include:
- Starting with a low dose of 2.5 mg and titrating up to 5 mg as needed and tolerated
- Being aware of potential interactions with other medications, such as nitrates
- Monitoring for side effects, such as headache, indigestion, and muscle aches
- Considering alternative dosing regimens, such as as-needed dosing, for patients who prefer a more flexible schedule. It's also important to note that daily Cialis has been shown to be effective in improving erectile dysfunction in diabetic men, as mentioned in 1. Overall, daily Cialis can be a effective and convenient treatment option for erectile dysfunction, but it's essential to follow the recommended dosing guidelines and consult with a healthcare provider to determine the best course of treatment.
From the FDA Drug Label
The recommended starting dose of tadalafil tablets for once daily use is 2.5 mg, taken at approximately the same time every day, without regard to timing of sexual activity. The tadalafil tablets dose for once daily use may be increased to 5 mg, based on individual efficacy and tolerability.
The recommended dose of tadalafil tablets for once daily use is 5 mg, taken at approximately the same time every day, without regard to timing of sexual activity.
The daily dosing for Cialis (tadalafil) is:
- 2.5 mg per day, which may be increased to 5 mg per day, based on individual efficacy and tolerability, for Erectile Dysfunction.
- 5 mg per day for Benign Prostatic Hyperplasia and Erectile Dysfunction/Benign Prostatic Hyperplasia 2.
From the Research
Daily Dosing for Cialis
- The daily dosing for Cialis (tadalafil) is typically 2.5 mg or 5 mg once daily 3, 4, 5.
- A study published in 2016 found that tadalafil 2.5 mg and 5 mg once daily were effective in improving erectile function in patients with erectile dysfunction 3.
- Another study published in 2018 found that tadalafil daily scored on average 1.82 points higher in International Index for Erectile Dysfunction-Erectile Function domain scores compared to on-demand dosing 4.
- A 2020 study found that daily tadalafil 5 mg monotherapy increased the IIEF-EF score from 14.8 ± 6.9 to 20.8 ± 7.3, and combination therapy with L-Arginine 2,500 mg further increased the score to 22 ± 7.5 5.
Comparison of Daily and On-Demand Dosing
- Studies have compared the efficacy of daily and on-demand dosing of tadalafil, with some finding that daily dosing may be more effective in certain patient populations 3, 4.
- However, other studies have found that the difference between daily and on-demand dosing may not be clinically significant 4.
Safety and Tolerability
- Tadalafil daily dosing has been found to be safe and well-tolerated, with common side effects including headache, facial flushing, nasal congestion, and dyspepsia 6, 5.
- A 2020 study found that combination therapy with L-Arginine 2,500 mg and tadalafil 5 mg daily had a higher incidence of adverse events compared to monotherapy 5.