From the Research
Lanreotide can cause mood swings as a side effect due to its impact on hormone regulation in the body, particularly through its effects on somatostatin, which has been linked to mood disorders 1. This medication is a somatostatin analog that suppresses the release of growth hormone, insulin-like growth factor-1 (IGF-1), and other hormones involved in endocrine function. When lanreotide alters these hormone levels, it can affect neurotransmitters in the brain that regulate mood, such as serotonin and dopamine. Some key points to consider include:
- Lanreotide's effects on hormone regulation can lead to changes in blood glucose levels, potentially causing hypoglycemia or hyperglycemia, which can manifest as irritability, anxiety, or mood changes 2.
- The medication can also cause fatigue, sleep disturbances, and gastrointestinal symptoms like nausea or diarrhea, which may indirectly contribute to mood alterations.
- Patients taking lanreotide (typically administered as Somatuline Depot in doses ranging from 60-120 mg every 4 weeks) should monitor their mood changes and discuss them with their healthcare provider, who might adjust the dosage or recommend supportive strategies to manage these effects 3.
- It is essential to note that the safety profile of lanreotide is generally well-tolerated, with low rates of treatment discontinuation due to toxicity 3.
- Recent studies have explored the role of glutamatergic modulators in treating mood disorders, which may provide new avenues for managing lanreotide-induced mood swings 4, 5. Overall, patients taking lanreotide should be aware of the potential for mood swings and work closely with their healthcare provider to manage these effects and optimize their treatment plan.