From the Guidelines
Lanreotide can cause mood swings due to its impact on hormone levels and neurotransmitter function in the body. This somatostatin analogue binds to somatostatin receptor subtypes 2 and 5, inhibiting the release of various peptide hormones in the gut, pancreas, and pituitary, as stated in the guidelines for the management of gastroenteropancreatic neuroendocrine tumours 1. The fluctuation of hormone levels, such as growth hormone, insulin, and glucagon, can affect brain chemistry and lead to changes in mood. Furthermore, lanreotide may alter thyroid function in some patients, and thyroid hormones play a significant role in regulating mood.
Some of the key points to consider when evaluating the potential for lanreotide to cause mood swings include:
- The medication's mechanism of action, which involves inhibiting hormone release and affecting neurotransmitter function
- The potential for lanreotide to cause side effects like fatigue, headaches, and gastrointestinal issues, which can contribute to irritability and mood changes
- The importance of monitoring patients for mood swings and adjusting treatment as needed to minimize these effects
- The variability in individual responses to lanreotide, with some patients experiencing minimal emotional changes while others may have more pronounced effects
It is essential for patients taking lanreotide who experience significant mood swings to discuss these symptoms with their healthcare provider, as dosage adjustments or additional supportive treatments may help manage these effects, as recommended in the guidelines for the management of gastroenteropancreatic neuroendocrine tumours 1.
From the Research
Lanreotide and Mood Swings
- The exact mechanism of lanreotide causing mood swings is not directly stated in the provided studies 2, 3, 4, 5, 6.
- However, it can be inferred that lanreotide, as a somatostatin analogue, may affect neuroendocrine function, which in turn could influence mood regulation 5.
- Somatostatin analogues like lanreotide can alter the secretion of various hormones, including those involved in mood regulation, such as serotonin and cortisol 5.
- Changes in hormone levels, particularly those involved in the serotonin system, can impact mood and may contribute to mood swings 4, 5.
- Additionally, lanreotide's effects on insulin-like growth factor system and metabolic parameters may also play a role in mood regulation, although the exact relationship is not clearly established 6.