What is Multiple Myeloma (MNM)?

From the Guidelines

MNM is most likely referring to Multiple Myeloma, a malignant neoplasm of plasma cells that accumulate in bone marrow, leading to bone destruction and marrow failure, as this is the most relevant definition in the context of the provided evidence. The definition of MNM can vary depending on the context in which it is used. However, based on the provided evidence, it appears that MNM is being referred to as Multiple Myeloma, a type of blood cancer characterized by the proliferation of malignant plasma cells in the bone marrow. Some key points to consider when evaluating MNM as Multiple Myeloma include:

• The disease is typically sensitive to a variety of cytotoxic drugs, both as initial treatment and as treatment for relapsed disease, as noted in the study by 1.
• The treatment of Multiple Myeloma has dramatically improved over the past decade, with the introduction of new classes of drugs, such as immunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, and histone deacetylase inhibitors, as discussed in the study by 1.
• The diagnosis of symptomatic Multiple Myeloma requires the presence of end-organ damage, such as hypercalcemia, renal failure, anemia, and bone disease, as outlined in the study by 1.
• The management of newly diagnosed symptomatic Multiple Myeloma should be guided by disease- and patient-related factors, including risk stratification, primarily based on cytogenetic features, as recommended in the study by 1. It is essential to note that the specific meaning of MNM depends entirely on the field or situation in which it's being used, and without additional context, it's difficult to provide a more specific answer about which definition of MNM is most relevant to the needs of the individual. However, in the context of the provided evidence, the most likely definition of MNM is Multiple Myeloma, and it is crucial to consider the latest research and guidelines, such as those outlined in the study by 1, when evaluating and managing this disease.

From the Research

Definition of MNM

There is no direct information available in the provided studies to define what MNM stands for.

Mefloquine Information

However, the studies do provide information about mefloquine, which is an antimalarial agent. Here are some key points about mefloquine:

• Mefloquine is one of four antimalarial agents commonly recommended for preventing malaria in travelers to malaria-endemic areas 2.
• Mefloquine has high efficacy but is associated with psychological side effects such as abnormal dreams, insomnia, anxiety, and depressed mood 2, 3.
• The choice of antimalarial agent depends on how individual travelers assess the importance of specific adverse effects, pill burden, and cost 2.
• Mefloquine is often prescribed for children and pregnant women, but it is occasionally prescribed for patients with comorbidities listed as contraindications 3.

Comparison with Other Antimalarial Agents

Here are some key points about the comparison of mefloquine with other antimalarial agents:

• Mefloquine users were more likely to discontinue their medication due to adverse effects than atovaquone-proguanil users 2.
• Mefloquine users were more likely to report abnormal dreams, insomnia, anxiety, and depressed mood than atovaquone-proguanil users 2.
• Mefloquine users were less likely to report dyspepsia, photosensitivity, vomiting, and vaginal thrush than doxycycline users 2.
• Atovaquone-proguanil and doxycycline are the best tolerated regimens, and mefloquine is associated with adverse neuropsychiatric outcomes 4.