From the Research
The maximum recommended daily dose of Wellbutrin (bupropion) is 450 mg, and it should not be exceeded due to the increased risk of seizures and other adverse effects, as supported by the most recent study 1. The dosage of Wellbutrin depends on the specific formulation being used, with different maximum daily doses for immediate-release, sustained-release, and extended-release forms.
- For immediate-release Wellbutrin, the maximum recommended daily dose is 450 mg, typically given as 150 mg three times daily with at least 6 hours between doses.
- For Wellbutrin SR (sustained-release), the maximum daily dose is also 400 mg, usually given as 200 mg twice daily.
- For Wellbutrin XL (extended-release), the maximum daily dose is 450 mg taken once daily in the morning. It's essential to start at a lower dose and gradually increase to reduce the risk of side effects, particularly seizures, which are a dose-dependent risk with bupropion, as noted in 2 and 3. The medication should not be taken in larger amounts than prescribed, as this increases seizure risk significantly, and patients with certain conditions like seizure disorders, eating disorders, or those undergoing abrupt discontinuation of alcohol or sedatives have higher seizure risks and may require lower maximum doses, as discussed in 4 and 5. Wellbutrin works by affecting brain chemicals norepinephrine and dopamine, which influence mood and are thought to be imbalanced in depression. Always take Wellbutrin exactly as prescribed by your healthcare provider, as individual dosing may vary based on your specific medical situation.