What is the recommended duration of treatment for mastitis with cephalexin (Cefalexin)?

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Last updated: May 18, 2025 • View editorial policy

From the Research

Cephalexin treatment for mastitis typically lasts 10-14 days, with 10 days being a common recommendation. The standard adult dosage is 500 mg taken orally every 6 hours (four times daily), though some providers may prescribe 500 mg every 8 hours (three times daily) 1. It's crucial to complete the entire prescribed course of antibiotics even if symptoms improve before finishing the medication, as stopping early can lead to recurrence or antibiotic resistance. Cephalexin works by inhibiting bacterial cell wall synthesis, effectively treating the Staphylococcus aureus and Streptococcus species that commonly cause mastitis.

While taking the antibiotic, continue to empty the breast regularly through breastfeeding or pumping, apply warm compresses before feeding, ensure proper latch if breastfeeding, and take anti-inflammatory pain medication as needed. Contact your healthcare provider if symptoms worsen or don't begin to improve within 48 hours of starting treatment. The choice of a proper treatment and the provision of therapeutic instructions to the patient are crucial for a cure, for a successful duration of breastfeeding, and for preventing complications for mother and baby 1.

Some key points to consider when treating mastitis with cephalexin include:

  • The importance of completing the full course of antibiotics to prevent recurrence or antibiotic resistance
  • The need to continue breastfeeding or pumping to empty the breast regularly
  • The use of warm compresses and proper latch technique to promote healing and prevent further complications
  • The potential for adverse effects in infants, although these are typically minor and self-limiting 2
  • The importance of monitoring for signs of improvement or worsening symptoms and contacting a healthcare provider if necessary.

Overall, the goal of treatment is to effectively manage symptoms, prevent complications, and support the continuation of breastfeeding, which is beneficial for both mother and baby 1.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.