From the Research
Memory loss or cognitive dysfunction associated with pancreatic tumors is a complex condition that requires prompt medical evaluation and treatment of the underlying tumor. The relationship between pancreatic tumors and cognitive symptoms is multifaceted, involving potential paraneoplastic syndromes, secretion of substances affecting cognition, metabolic disturbances, nutritional deficiencies, and in some cases, brain metastasis 1. Depression and anxiety, common among cancer patients, can further exacerbate cognitive difficulties. Management should focus on treating the pancreatic tumor through surgery, chemotherapy, or radiation, alongside addressing specific cognitive symptoms with appropriate medications and cognitive rehabilitation. Notably, the use of metformin has been explored in the context of pancreatic cancer, with some studies suggesting a potential survival benefit, particularly in patients who have undergone pancreatectomy 2, 3. However, the evidence regarding metformin's effect on cognitive symptoms specifically in pancreatic cancer patients is limited. Given the complexity of this condition, early detection and treatment of pancreatic cancer are crucial for improving outcomes, including reducing the risk of cognitive dysfunction. Patients experiencing unexplained cognitive changes should seek medical evaluation promptly. In terms of management, a comprehensive approach addressing both the underlying pancreatic tumor and the cognitive symptoms is essential for optimizing patient outcomes.