From the Research
The starting dose of ketamine lozenge is typically 25-50 mg, with 25 mg being a common starting point to assess individual response and tolerance. This dose range is based on the most recent and highest quality study available, which suggests that oral ketamine can be effective in treating depression and chronic pain, with doses ranging from 0.25 to 7 mg/kg and from 50 mg to 300 mg per occasion 1. When considering the starting dose, it's essential to prioritize the patient's safety and minimize the risk of adverse effects. Starting at a lower dose, such as 25 mg, allows the body to acclimate to the medication while reducing the risk of adverse effects. The dose can be adjusted upward as needed under medical supervision, and patients should use ketamine lozenges only under close medical supervision due to their potential for side effects and abuse. Key considerations for ketamine lozenge dosing include:
- Starting at a low dose to assess individual response and tolerance
- Adjusting the dose upward as needed under medical supervision
- Using the medication under close medical supervision to minimize the risk of adverse effects and abuse
- Storing the medication securely and out of reach of others Ketamine works as an NMDA receptor antagonist, which is thought to rapidly increase neuroplasticity and potentially alleviate symptoms of depression and chronic pain, making it a valuable treatment option for patients who have not responded to other therapies 2.