What vitamins and supplements are effective for treating Premenstrual Dysphoric Disorder (PMDD)?

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Last updated: May 19, 2025 • View editorial policy

From the Research

Vitamins and supplements are not the primary treatment for Premenstrual Dysphoric Disorder (PMDD), and selective serotonin reuptake inhibitors (SSRIs) and cognitive behavioral therapy (CBT) are the most commonly recommended treatments. According to the most recent study 1, SSRIs, such as sertraline, fluoxetine, and escitalopram, are effective in reducing PMDD symptoms. CBT has also shown positive results in reducing functional impairment, depressed mood, and anxiety. While some studies suggest that omega-3 fatty acids 2 and other supplements may have a beneficial effect on PMDD symptoms, the evidence is not as strong as it is for SSRIs and CBT.

Key Considerations

  • The most effective treatment for PMDD is often a combination of medication and therapy, with SSRIs being the most commonly prescribed medication 1.
  • CBT is a valuable adjunct to medication, helping to reduce functional impairment and improve overall quality of life 1.
  • Omega-3 fatty acids may have a beneficial effect on PMDD symptoms, particularly in reducing depression, anxiety, and bloating 2.
  • Other supplements, such as calcium, vitamin B6, and magnesium, may also be helpful in reducing PMDD symptoms, but the evidence is less robust.

Recommendations

  • Consult with a healthcare provider to determine the best course of treatment for PMDD, as individual needs and circumstances can vary.
  • Consider starting with SSRIs or CBT, as these are the most well-established treatments for PMDD.
  • If supplements are being considered, start with one at a time to monitor effectiveness and potential interactions with other medications.
  • Lifestyle changes, such as regular exercise, stress management, and a balanced diet, can also help alleviate PMDD symptoms.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.