What is the significance of absent hair on the ankles in a male?

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From the Guidelines

Hair loss on the ankles in men can be a sign of low testosterone levels, as testosterone plays a role in the growth and maintenance of body hair. According to the study 1, testosterone deficiency in males is associated with a range of symptoms, including decreased body hair. The normal total testosterone range for adult men is 300 to 800 ng/dL, and levels below this range may indicate hypogonadism, a condition characterized by low testosterone production. Some key points to consider include:

  • Testosterone replacement therapy may be considered for men with low testosterone levels, particularly those with symptoms such as decreased energy, libido, and body hair.
  • The diagnosis of hypogonadism typically involves measuring morning total testosterone concentration, as well as free testosterone level by equilibrium dialysis and sex hormone-binding globulin level in patients with obesity.
  • Treatment with testosterone-replacement therapy should be considered when the morning free testosterone by equilibrium dialysis is frankly low on at least 2 separate assessments, and the hypogonadism workup has been completed to rule out an etiology of hypogonadism unrelated to obesity, as stated in the study 1. It is essential to consult a healthcare provider if you notice hair loss on your ankles, especially if accompanied by other symptoms such as decreased energy, libido, or muscle mass, to determine the underlying cause and appropriate treatment.

From the Research

Signs of Hypogonadism in Men

  • Low serum testosterone levels can lead to various symptoms, including changes in physical characteristics
  • One possible sign of hypogonadism in men is the lack of hair on the ankles, although this is not explicitly mentioned in the provided studies 2, 3, 4, 5, 6

Relationship Between Testosterone and Hair Growth

  • Testosterone plays a role in the development of secondary sex characteristics, including hair growth 4
  • However, the specific relationship between testosterone levels and hair growth on the ankles is not discussed in the provided studies

Diagnosis and Treatment of Hypogonadism

  • Hypogonadism is typically diagnosed based on symptoms and low serum testosterone levels 4, 5
  • Treatment options, such as testosterone replacement therapy, are available to alleviate symptoms and improve quality of life 2, 4, 5, 6

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Testosterone Replacement Therapy in Hypogonadal Men.

Endocrinology and metabolism clinics of North America, 2022

Research

The interrelationships between thyroid dysfunction and hypogonadism in men and boys.

Thyroid : official journal of the American Thyroid Association, 2004

Research

Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline.

The Journal of clinical endocrinology and metabolism, 2018

Research

Hypogonadism: Therapeutic Risks, Benefits, and Outcomes.

The Medical clinics of North America, 2018

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Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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