From the Research
Imvexy (estradiol vaginal insert) should be inserted into the vagina once daily for 2 weeks, then reduced to twice weekly maintenance dosing, with the 4 mcg dose typically recommended to start, as supported by the study published in Menopause (New York, N.Y.) in 2019 1. The dosing regimen for Imvexy is designed to deliver estrogen directly to vaginal tissues, helping to restore thickness and elasticity to vaginal walls, increase lubrication, and reduce discomfort associated with menopausal vulvar and vaginal atrophy (VVA) and moderate to severe dyspareunia. Some key points to consider when using Imvexy include:
- Each single-use applicator delivers 4 or 10 mcg of estradiol
- To use, remove the applicator from its packaging, hold it by the thick end, and gently insert the smaller end into the vagina while lying on your back with knees bent
- Push the plunger to release the medication, then remove and discard the applicator
- For best absorption, insert at the same time each day, preferably in the evening before bedtime
- Wash your hands before and after application The study published in Current medical research and opinion in 2018 2 also supports the safety and efficacy of Imvexy for treating moderate to severe dyspareunia associated with menopausal VVA, with minimal systemic absorption of estrogen. It's essential to note that Imvexy is a localized hormone therapy, which reduces the risks associated with systemic hormone therapy, as mentioned in the study published in The journal of sexual medicine in 2011 3. If you experience unusual bleeding, discharge, or irritation while using Imvexy, contact your healthcare provider, as they can provide guidance on how to manage these symptoms and ensure the safe use of the medication.