Differential Diagnosis for Daily Headaches Following Post IV Iron Infusion
- Single most likely diagnosis
- Iron infusion headache: This is a common side effect of IV iron infusions, often due to histamine release or an allergic reaction. The headache typically resolves on its own within a few days.
- Other Likely diagnoses
- Dehydration: IV iron infusions can cause dehydration, leading to headaches. Ensuring adequate hydration may help alleviate symptoms.
- Hypertension: Some patients may experience a temporary increase in blood pressure after IV iron infusion, which can cause headaches.
- Migraine or tension headache: These primary headache disorders can be triggered by various factors, including the stress of receiving an infusion.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Hypertensive emergency: Although rare, IV iron infusion can cause a severe increase in blood pressure, leading to a hypertensive emergency, which requires immediate medical attention.
- Anaphylaxis: A severe allergic reaction to the IV iron infusion can cause anaphylaxis, a life-threatening condition that requires prompt treatment.
- Cerebral venous sinus thrombosis: This rare but potentially deadly condition can occur in patients with a history of thrombosis or those taking estrogen-containing medications.
- Rare diagnoses
- Reversible cerebral vasoconstriction syndrome (RCVS): A rare condition characterized by temporary narrowing of the blood vessels in the brain, which can cause headaches and other symptoms.
- Iron overload: Although rare, excessive iron accumulation can cause various symptoms, including headaches, in patients with underlying conditions such as hemochromatosis.