What is the diagnosis for a patient with a history of Chronic Obstructive Pulmonary Disease (COPD) who complains of back pain and shortness of breath (SOB), has a history of vaping, and presents with impaired renal function, mild hematuria, and leukocytosis?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 20, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis

  • Single most likely diagnosis
    • Chronic musculoskeletal back pain: The patient's complaint of back pain, combined with a history of COPD and vaping, suggests a possible musculoskeletal origin, especially given the lack of acute findings on chest and abdomen X-rays.
  • Other Likely diagnoses
    • Acute bronchitis or exacerbation of COPD: The patient's history of COPD, shortness of breath (SOB), and vaping habit make an exacerbation of COPD or acute bronchitis a plausible diagnosis, despite the lack of specific findings on the chest X-ray.
    • Urinary tract infection (UTI): Although the urinalysis shows only a few bacteria and trace leukocyte esterase, the presence of WBCs (6-10/hpf) and RBCs (3-5/hpf) in the urine could indicate a mild or early UTI.
    • Chronic kidney disease (CKD): The elevated creatinine level (1.53) and decreased eGFR (46) suggest CKD, which could be contributing to the patient's back pain and other symptoms.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
    • Pneumonia: Despite the negative chest X-ray, pneumonia should be considered, especially in a patient with COPD and SOB, as it can be life-threatening if not promptly treated.
    • Pulmonary embolism (PE): Although less likely, PE is a critical diagnosis to consider in a patient with SOB, as it can be fatal if not recognized and treated promptly.
    • Spinal infection or osteomyelitis: Infection of the spine or vertebrae could present with back pain and should be considered, especially if the patient has risk factors such as immunocompromised status or recent instrumentation.
  • Rare diagnoses
    • Multiple myeloma: The presence of back pain, anemia (although mild), and renal impairment could suggest multiple myeloma, although this would be a less common diagnosis.
    • Sarcoidosis: This condition can cause back pain, renal impairment, and pulmonary symptoms, although it would be a less likely diagnosis without additional supporting evidence.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.