From the Research
Lacosamide can potentially cause dyskinesia, particularly in pediatric patients with underlying opercular dysfunction, as reported in a study published in 2020 1.
Overview of Lacosamide and Dyskinesia
Lacosamide is an antiepileptic drug that works by selectively enhancing slow inactivation of voltage-gated sodium channels, which helps stabilize hyperexcitable neuronal membranes. While it is generally well-tolerated, dyskinesia, characterized by involuntary muscle movements, has been reported in some patients taking lacosamide.
Risk Factors for Dyskinesia
The risk of dyskinesia may be higher in patients with pre-existing movement disorders, those on multiple antiepileptic drugs, or individuals with certain genetic predispositions affecting drug metabolism. A study published in 2020 found that pediatric patients with dysfunction of the opercular cortex are at increased risk for developing drug-induced dyskinesias on high-dose lacosamide therapy 1.
Management of Dyskinesia
If a patient develops dyskinesia while on lacosamide, it's essential not to abruptly discontinue the medication as this could precipitate seizures. Instead, the patient should consult their healthcare provider, who might consider dose adjustment, gradual discontinuation, or switching to an alternative medication.
Common Side Effects of Lacosamide
More commonly reported neurological side effects of lacosamide include:
- Dizziness
- Headache
- Diplopia
- Coordination abnormalities
Recent Studies on Lacosamide
A 2021 Cochrane review found that lacosamide is effective and well-tolerated in the short term when used as add-on treatment for drug-resistant focal epilepsy 2. Another study published in 2022 found that lacosamide add-on led to simplification of the previous drug regimen and reduction in seizure frequency in patients with drug-resistant epilepsy and severe disability under polytherapy 3.