Differential Diagnosis for Jaundice, Skin Hyperpigmentation, and Weight Loss
Single Most Likely Diagnosis
- Pancreatic Cancer: This diagnosis is likely due to the combination of jaundice (which can be caused by bile duct obstruction), weight loss, and skin hyperpigmentation (which can be caused by increased ACTH production in some cases of pancreatic cancer).
Other Likely Diagnoses
- Cholangiocarcinoma: A type of cancer that affects the bile ducts, which can cause jaundice and weight loss. Skin hyperpigmentation can occur due to increased bilirubin levels.
- Primary Sclerosing Cholangitis (PSC): A chronic liver disease that can cause jaundice, weight loss, and skin hyperpigmentation due to chronic inflammation and scarring of the bile ducts.
- Hemochromatosis: A genetic disorder that causes excessive iron absorption, leading to skin hyperpigmentation, weight loss, and potentially jaundice due to liver damage.
Do Not Miss Diagnoses
- Hepatocellular Carcinoma: A type of liver cancer that can cause jaundice, weight loss, and skin hyperpigmentation. Although less common, it is a critical diagnosis to consider due to its poor prognosis if left untreated.
- Lymphoma: Certain types of lymphoma, such as primary hepatic lymphoma, can cause jaundice, weight loss, and skin hyperpigmentation. Early diagnosis is crucial for effective treatment.
Rare Diagnoses
- Porphyria Cutanea Tarda: A rare genetic disorder that causes skin hyperpigmentation, blistering, and increased hair growth. Jaundice and weight loss can occur in some cases due to liver damage.
- Wilson's Disease: A rare genetic disorder that causes excessive copper accumulation in the body, leading to liver damage, jaundice, weight loss, and potentially skin hyperpigmentation.