From the Research
Insulin resistance in Williams syndrome should be managed with a combination of lifestyle modifications and medication, prioritizing metformin as the first-line treatment, to mitigate the risk of cardiovascular complications and improve quality of life. The management of insulin resistance in Williams syndrome is crucial to prevent the progression of metabolic dysfunction and cardiovascular disease. Key components of treatment include:
- Regular physical activity, such as at least 150 minutes of moderate exercise per week
- A low-glycemic diet rich in vegetables, lean proteins, and complex carbohydrates
- Blood glucose monitoring, with HbA1c levels checked every 3-6 months, aiming for targets below 7% 1 The use of metformin, starting at 500mg daily and potentially increasing to 1000mg twice daily as needed, is supported by recent studies on the management of type 2 diabetes, which highlight the importance of early intervention to prevent cardiovascular complications 2, 3, 4. Additionally, the unique genetic characteristics of Williams syndrome, including the hemizygous deletion of genes on chromosome 7q11.23, contribute to the development of insulin resistance and metabolic dysfunction 5. Therefore, a comprehensive treatment approach that addresses lifestyle modifications, medication, and regular monitoring is essential to improve outcomes and quality of life for individuals with Williams syndrome.