From the Research
Buspar (buspirone) is not recommended as a first-line treatment for anxiety in patients with Parkinson's disease due to concerns about its tolerability and potential to worsen motor function. According to a study published in 2020 1, buspirone was found to be poorly tolerated in patients with Parkinson's disease, with 41% of participants failing to complete the study due to intolerability. Additionally, 53% of participants experienced adverse events consistent with worsened motor function. While buspirone may be effective in reducing anxiety symptoms, its potential risks and side effects must be carefully considered in patients with Parkinson's disease.
Key Considerations
- The study found that buspirone was initiated at 7.5 mg twice daily and titrated based on response and tolerability to an optimal dosage (maximum 30 mg twice daily) 1.
- The median buspirone dosage was 7.5 mg twice daily, and no serious adverse events occurred 1.
- However, the study's findings suggest that buspirone may not be suitable for all patients with Parkinson's disease, particularly those with significant motor symptoms or those taking concomitant medications that may interact with buspirone 1.
Alternative Treatments
- Other treatments, such as cognitive-behavioral therapy or other anti-anxiety medications, may be more effective and better tolerated in patients with Parkinson's disease 2.
- Exercise and physical activity have also been shown to be beneficial in managing Parkinson's disease symptoms, including anxiety and motor function 3, 4, 5.
- A systematic review and network meta-analysis published in 2024 found that various types of physical exercise, including dance, gait/balance/functional training, and multi-domain training, may have beneficial effects on motor signs and quality of life in patients with Parkinson's disease 5.
Monitoring and Management
- Patients with Parkinson's disease who are prescribed buspirone should be closely monitored for potential side effects, such as dizziness, headache, or nausea, and the medication should always be prescribed and managed by a healthcare provider familiar with both the patient's Parkinson's condition and their anxiety symptoms.
- Regular follow-up appointments and adjustments to the treatment plan as needed can help minimize the risks associated with buspirone use in patients with Parkinson's disease.