From the Guidelines
Simethicone is generally well-tolerated, but it can cause dose-dependent side effects such as bloating and flatulence, which may limit its use in clinical practice. These side effects are common and may be a concern for some patients 1. In addition to bloating and flatulence, simethicone may also cause other mild side effects such as belching, gas, or mild stomach discomfort. Allergic reactions to simethicone are extremely rare but could include rash, itching, swelling, dizziness, or trouble breathing.
The medication works by breaking down gas bubbles in the digestive tract, allowing them to be more easily expelled from the body rather than causing bloating and discomfort. It is not absorbed into the bloodstream, which explains its minimal side effect profile. Simethicone is generally considered safe for adults and children when used as directed, including during pregnancy and breastfeeding, though you should always consult a healthcare provider before using any medication during these times.
Some studies have suggested that simethicone may be associated with other side effects, such as headache, abdominal pain, nausea, and diarrhea 1. However, these side effects are not well-established and may not be directly related to simethicone use.
In terms of dosage, the US Multi-Society Task Force on Colorectal Cancer recommends using a dose of at least 320 mg of simethicone if it is included in a bowel preparation regimen 1. The task force also suggests using the lowest possible dilution of simethicone and administering it only through an instrument channel that is routinely brushed during endoscope reprocessing 1.
Overall, while simethicone is generally well-tolerated, it can cause some side effects, and patients should be aware of these potential effects when using the medication. If you experience any unusual or persistent side effects while taking simethicone, discontinue use and consult with a healthcare professional.
Some key points to consider when using simethicone include:
- Simethicone can cause dose-dependent side effects such as bloating and flatulence
- The medication is generally considered safe for adults and children when used as directed
- Simethicone is not absorbed into the bloodstream, which explains its minimal side effect profile
- The US Multi-Society Task Force on Colorectal Cancer recommends using a dose of at least 320 mg of simethicone if it is included in a bowel preparation regimen
- Patients should be aware of the potential side effects of simethicone and discontinue use if they experience any unusual or persistent effects.
From the Research
Simethicone Side Effects
- The studies 2, 3 suggest that simethicone is generally well-tolerated, with no significant differences in rates of nausea, vomiting, and abdominal pain compared to placebo or standard treatment.
- However, simethicone has been shown to decrease abdominal bloating in patients undergoing bowel preparation for colonoscopy 2 and in patients with dyspeptic syndrome 3.
- The combination of simethicone and activated charcoal has been found to reduce symptoms of dyspeptic syndrome, including abdominal fullness, bloating, and slow digestion 3.
- Simethicone may improve colon cleanliness and adenoma detection rate in patients undergoing colonoscopy, particularly when used in combination with polyethylene glycol (PEG) 2.
Common Side Effects
- Abdominal bloating: decreased with simethicone use 2, 3
- Nausea: no significant difference with simethicone use 2
- Vomiting: no significant difference with simethicone use 2
- Abdominal pain: no significant difference with simethicone use 2