What is the diagnosis for a 59-year-old male with a 5-day history of erythema (redness) and pain underneath the 2nd and 3rd toes, described as a painful nodule, accompanied by difficulty walking and lateral great toe erythema, which has since improved?

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Differential Diagnosis for 59-year-old Male with Toe Pain and Redness

  • Single most likely diagnosis:
    • Interdigital neuroma (Morton's neuroma): This condition is characterized by a painful, swollen mass in the ball of the foot, often between the toes, which matches the patient's symptoms of a painful ball under the 2nd and 3rd toes. The improvement in symptoms could be due to reduced pressure on the affected area.
  • Other Likely diagnoses:
    • Ingrown toenail: The redness on the lateral side of the great toe could be indicative of an ingrown toenail, which is a common cause of toe pain and redness.
    • Bursitis: Inflammation of the bursae (fluid-filled sacs) under the toes could cause pain and redness, especially if the patient has been putting pressure on the area.
    • Gout: Although less common in the toes other than the big toe, gout could still be a consideration, especially if the patient has a history of the condition.
  • Do Not Miss (ddxs that may not be likely, but would be deadly if missed):
    • Osteomyelitis: A bone infection that could cause pain, redness, and swelling in the foot, which might not be immediately apparent but requires prompt treatment to avoid serious complications.
    • Cellulitis with abscess: A bacterial skin infection that could lead to serious consequences, such as sepsis, if not treated promptly.
    • Deep vein thrombosis (DVT): Although less common in the foot, DVT could cause pain and swelling, and it's essential to consider this diagnosis due to its potential for severe complications, such as pulmonary embolism.
  • Rare diagnoses:
    • Erythromelalgia: A rare disorder characterized by burning pain, redness, and heat in the hands and feet, which could be a consideration if other diagnoses are ruled out.
    • Complex regional pain syndrome (CRPS): A rare condition characterized by chronic pain, inflammation, and sensitivity in one of the limbs, which might be a possibility if the patient's symptoms persist or worsen over time.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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