From the Guidelines
For a 2-year-old female, the recommended dose of ceftriaxone is 50-75 mg/kg/day, typically given once daily or divided into two doses, as stated in the most recent and highest quality study 1.
Key Considerations
- The dose of ceftriaxone should be calculated based on the child's weight, with a maximum daily dose not exceeding 2 grams.
- Ceftriaxone is administered via intramuscular injection or intravenous infusion.
- The duration of treatment typically ranges from 5-14 days, depending on the type and severity of infection.
Important Details
- Ceftriaxone is a third-generation cephalosporin effective against many gram-positive and gram-negative bacteria.
- It is suitable for various infections, including pneumonia, meningitis, and urinary tract infections.
- Renal and hepatic function should be monitored during treatment, and the child should be observed for potential side effects such as diarrhea or allergic reactions.
Calculation of Dose
- For example, if the child weighs 12 kg, the dose would be 600-900 mg per day, as calculated based on the recommended dose range of 50-75 mg/kg/day.
References
The recommended dose is based on the study by 1, which provides guidelines for antibiotic prescribing in children. Other studies, such as 1, 1, 1, and 1, also provide information on ceftriaxone dosing, but 1 is the most recent and highest quality study.
From the FDA Drug Label
For the treatment of skin and skin structure infections, the recommended total daily dose is 50 to 75 mg/kg given once a day (or in equally divided doses twice a day). For the treatment of acute bacterial otitis media, a single intramuscular dose of 50 mg/kg (not to exceed 1 gram) is recommended
The dose of ceftriaxone for a 2-year-old female depends on the type and severity of infection.
- For skin and skin structure infections: 50 to 75 mg/kg per day, given once a day or in divided doses twice a day.
- For acute bacterial otitis media: a single intramuscular dose of 50 mg/kg, not to exceed 1 gram. To determine the dose, the child's weight in kilograms must be known, as the dose is weight-based. 2 3
From the Research
Ceftriaxone Dosage for a 2-Year-Old Female
- The dosage of ceftriaxone for a 2-year-old female can be determined based on the study 4, which suggests a dose of 100 mg/kg once daily for critically ill children.
- According to the study 4, for a typical patient with an estimated glomerular filtration rate of 80 mL/min/1.73 m2, the current 100-mg/kg once-daily dose results in a probability of target attainment of 96.8% and 60.8% for a MIC of 0.5 mg/L and 4 × MIC (2 mg/L), respectively.
- However, the study 4 also suggests that a twice-daily dosing regimen of 50 mg/kg can be considered to improve target attainment in patients with an estimated glomerular filtration rate of > 80 mL/min/1.73 m2 or in areas with a high prevalence of less-susceptible pathogens (MIC ≥ 0.5 mg/L).
- It is essential to note that the dosage may vary depending on the specific infection, severity of illness, and other factors, and should be determined by a healthcare professional.
- The other studies 5, 6, 7, 8 do not provide specific dosage recommendations for a 2-year-old female, but rather discuss the efficacy and safety of ceftriaxone in various infections and patient populations.