From the Guidelines
Alternatives to Voltaren 1% gel (diclofenac sodium) include topical NSAIDs like Flector patches (diclofenac epolamine) and over-the-counter options containing menthol, camphor, or lidocaine, as conditionally recommended by the American College of Rheumatology in 2012 1. When considering alternatives, it's essential to note that the American College of Rheumatology conditionally recommends the use of topical NSAIDs for the initial management of knee OA, as stated in their 2012 guidelines 1.
- Topical NSAIDs, such as diclofenac gel, have been shown to be effective in reducing pain and improving function in patients with knee OA, with a number needed to treat to gain a 20% reduction in pain (NNT20) of 6.8, as reported in a study published in the Annals of the Rheumatic Diseases in 2000 1.
- Other alternatives include:
- Over-the-counter options containing menthol, camphor, or lidocaine, which provide pain relief through different mechanisms
- Prescription alternatives like topical ketoprofen 10% gel and compounded diclofenac in higher strengths
- Non-NSAID options, such as capsaicin creams (0.025-0.075%), which can be effective by depleting substance P in nerve endings, although the American College of Rheumatology conditionally recommends against the use of topical capsaicin in their 2012 guidelines 1
- CBD-infused topicals, which may help with inflammation and pain, although evidence is limited It's crucial to follow package directions for application frequency and duration and consider that different active ingredients may provide better results for specific conditions. Additionally, healthcare providers should be aware of the warnings and precautions associated with the use of these agents, particularly in patients with contraindications or those taking concomitant medications that may interact with NSAIDs, as highlighted in the American College of Rheumatology's 2012 guidelines 1.
From the FDA Drug Label
11 DESCRIPTION Diclofenac sodium topical solution USP, 2% w/w, contains diclofenac sodium, USP a benzeneacetic acid derivative that is a nonsteroidal anti-inflammatory drug, and is available as a clear, colorless to faintly pink or orange solution for topical application.
The FDA drug label does not answer the question.
From the Research
Alternatives for Voltaren 1% Gel
Alternatives for Voltaren 1% gel can be considered based on the active ingredient, diclofenac sodium, and its various formulations. Some options may include:
- Other topical NSAIDs, such as ibuprofen or ketoprofen gels
- Oral NSAIDs, such as diclofenac sodium tablets or capsules
- Topical capsaicin creams or patches
- Topical salicylate creams or ointments
Efficacy and Safety of Topical Diclofenac Sodium
Studies have shown that topical diclofenac sodium 1% gel is effective in relieving pain and improving function in patients with osteoarthritis, with minimal side effects 2, 3. The efficacy and safety of topical diclofenac sodium have been compared to oral diclofenac sodium, with results suggesting that the topical formulation has a better tolerability profile, especially in terms of gastrointestinal side effects 4.
Other Uses of Diclofenac Sodium
Diclofenac sodium has also been used in the treatment of actinic keratoses, a type of skin lesion that can progress to squamous cell carcinoma 5, 6. Topical diclofenac sodium gel has been shown to be effective in treating actinic keratoses, with a favorable safety profile.
Key Considerations
When considering alternatives to Voltaren 1% gel, it is essential to weigh the potential benefits and risks of each option, taking into account the individual patient's medical history, age, and other factors. The choice of treatment should be based on the specific condition being treated, as well as the patient's overall health status. Some key points to consider include:
- Efficacy: How effective is the alternative treatment in relieving pain and improving function?
- Safety: What are the potential side effects of the alternative treatment, and how do they compare to those of Voltaren 1% gel?
- Convenience: How easy is the alternative treatment to use, and how often does it need to be applied?
- Cost: What is the cost of the alternative treatment, and how does it compare to the cost of Voltaren 1% gel?