From the Research
The best time to take Dayvigo (lemborexant) is about 30 minutes before bedtime, as it begins working relatively quickly and can help improve sleep onset latency, wake after sleep onset, and sleep efficiency, as shown in a systematic review and meta-analysis of 1976 patients 1. When taking Dayvigo, it's essential to establish a consistent sleep schedule and take it at approximately the same time each night.
- Take Dayvigo right before you plan to go to sleep and when you have at least 7 hours available for sleep before you need to be active again.
- Don't take Dayvigo with or immediately after a high-fat or heavy meal, as this can delay its effects and reduce its effectiveness.
- If you miss your dose and it's within 7 hours of your planned waking time, skip that dose to avoid morning drowsiness that could impair driving or other activities requiring alertness. A recent study published in 2025 found that lemborexant is an effective pharmacotherapy for the treatment of insomnia, with both 5-mg and 10-mg doses being well tolerated, although somnolence was more common relative to placebo 1. Another study published in 2024 found that lemborexant improved subject-reported efficacy in adults aged 65 years and older with insomnia, with improvements sustained through 12 months of treatment 2. Overall, the evidence suggests that taking Dayvigo 30 minutes before bedtime, with a consistent sleep schedule, and avoiding high-fat or heavy meals can help improve sleep quality and reduce the risk of morning drowsiness, as supported by the highest quality study available 1.