From the FDA Drug Label
In the event of overdosage, treatment should be symptomatic and supportive. ... Manifestations were variable, but included ... dry mouth, and other adverse reactions similar to those seen in normal clinical experience [see Adverse Reactions (6)]. Gastrointestinal: ... dry mouth, ...
Omeprazole can cause dry mouth. This is listed as a potential adverse reaction in the drug label, both in the context of overdosage and in the postmarketing experience section 1 1.
- Key adverse reaction: Dry mouth
- Relevance to omeprazole: Directly mentioned in the drug label as a potential adverse reaction.
From the Research
Yes, omeprazole can cause dry mouth as a side effect, as reported in a study published in 1995 2. Omeprazole is a proton pump inhibitor (PPI) that reduces stomach acid production and is commonly used to treat conditions like acid reflux, GERD, and stomach ulcers. Dry mouth occurs in some patients taking omeprazole, as it can affect the salivary glands, reducing saliva production. Some key points to consider:
- If you experience dry mouth while taking omeprazole, you can try drinking more water, chewing sugar-free gum, using alcohol-free mouthwash, or avoiding caffeine and alcohol which can worsen dryness.
- A more recent study from 2025 3 discusses the management of dry mouth, highlighting the importance of good oral hygiene and the use of saliva substitutes.
- Another study from 2018 4 found that medication use, including PPIs like omeprazole, is significantly associated with dry mouth in older adults.
- It is essential to consult your healthcare provider if the dry mouth is severe or bothersome, as they might adjust your dosage or recommend a different medication.
- The benefits of treating your underlying condition with omeprazole typically outweigh the side effect of dry mouth, so it is crucial not to stop taking the medication without medical advice.