There are no official guidelines to assist in answering this question. I will search for relevant research papers instead.
From the FDA Drug Label
Zolpidem tartrate tablets should not be taken with or immediately after a meal. The recommended time to take Ambien (zolpidem) is right before bedtime, and it should not be taken with or immediately after a meal 1.
From the Research
Administration Timing
The recommended time to take Ambien (zolpidem) after eating is not explicitly stated in the provided studies. However, the studies do provide information on the pharmacokinetics of zolpidem:
- Peak plasma concentration (Tmax) of zolpidem-IR occurs in 45 to 60 minutes 2
- The terminal elimination half-life (t½) of zolpidem-IR is approximately 2.4 hours 2
Factors Affecting Administration
Some factors to consider when taking zolpidem:
- Food may affect the absorption of zolpidem, but the exact timing of administration in relation to meals is not specified in the studies
- The elderly and patients with hepatic impairment may require adjusted dosages 3
- Zolpidem is indicated for short-term treatment of insomnia, and its use should be tailored to individual patient needs 4, 3
Pharmacokinetics and Pharmacodynamics
Key points about the pharmacokinetics and pharmacodynamics of zolpidem: