Cefprozil Dosing for 11.52 kg Child
For a child weighing 11.52 kg, administer cefprozil 7.5 mL of the 125 mg/5 mL suspension twice daily (equivalent to 15 mg/kg/dose or 30 mg/kg/day total). This provides 172.8 mg per dose, given every 12 hours.
Dosing Calculation
The FDA-approved pediatric dosing for cefprozil is 30 mg/kg/day divided into two doses 1. For this 11.52 kg child:
- Total daily dose: 11.52 kg × 30 mg/kg = 345.6 mg/day
- Per-dose amount: 345.6 mg ÷ 2 = 172.8 mg per dose
- Volume per dose: 172.8 mg ÷ (125 mg/5 mL) = 6.9 mL (round to 7.5 mL for practical administration)
This twice-daily dosing regimen is supported by pharmacokinetic data showing that cefprozil achieves adequate plasma concentrations with a Cmax of approximately 10.86 mcg/mL at 15 mg/kg dosing, with a half-life of 1.24 hours in pediatric patients 1.
Clinical Context
Cefprozil is listed as an alternative second- or third-generation cephalosporin for treating Streptococcus pneumoniae infections in children 2, 3. The 30 mg/kg/day dosing has demonstrated:
- Clinical cure rates of 96.6% in acute otitis media 4
- Bacteriological success in 95% of pediatric patients 4
- Effective middle ear fluid penetration with concentrations approximating 1 mcg/mL at 6 hours post-dose 5
Important Caveats
Limitations of this dosing: Cefprozil at 30 mg/kg/day is most effective against organisms with MIC ≤1 mcg/mL 5. For penicillin-non-susceptible S. pneumoniae or beta-lactamase-producing H. influenzae, clinical failure rates may be higher due to reduced susceptibility 5, 6.
Duration: Standard treatment courses are 10 days for most indications 4, 6, 7.
Administration: Can be given with or without food, though food slightly delays time to peak concentration by 0.25-0.75 hours without affecting overall absorption 1.