From the FDA Drug Label
WARNING Acyclovir tablets is intended for oral ingestion only. The FDA drug label does not answer the question.
From the Research
Acyclovir capsules should not be opened or crushed, and acyclovir tablets should not be crushed, due to the potential risks of altering the drug's absorption, leading to overdose or underdosing, as highlighted in the study by 1. However, in certain situations where a patient has difficulty swallowing, it may be necessary to consider alternative administration methods. The most recent and highest quality study available on this topic is from 1, which emphasizes the importance of considering the potential consequences of crushing tablets or opening capsules. Some key points to consider when administering acyclovir to patients with swallowing difficulties include:
- Ensuring that the patient receives the full dose of the medication
- Mixing the medication with a small amount of liquid or soft food, such as applesauce or yogurt, to facilitate swallowing
- Consulting with a healthcare provider to confirm the appropriate dose and administration method It's also important to note that acyclovir is not an extended-release formulation, so crushing the tablet or opening the capsule may not alter its intended release pattern, as mentioned in the studies by 2, 3, 4, and 5. However, the potential risks associated with altering the drug's absorption, as highlighted in the study by 1, should be carefully considered, and alternative administration methods should be approached with caution. In practice, it is essential to weigh the potential benefits of alternative administration methods against the potential risks and to consult with a healthcare provider to determine the best course of action for each individual patient.