From the Research
I would not recommend taking vardenafil with doxepin without medical supervision due to potential interactions. Both medications can affect your heart rhythm and blood pressure, and when taken together, they may increase the risk of side effects such as dizziness, lightheadedness, or fainting. Vardenafil (a medication for erectile dysfunction) can lower blood pressure, while doxepin (an antidepressant) can affect heart rhythm. The combination might cause an unsafe drop in blood pressure, especially when changing positions.
According to a study published in 2006 1, PDE5 inhibitors like vardenafil can reduce blood pressure in healthy patients, with vardenafil 20 mg causing a decline of -7.5/-8 mm Hg. Another study from 2005 2 notes that PDE5 inhibitors can interact with other medications, including those that affect heart rhythm, and may cause hypotension if taken with nitrates.
It's essential to consider the potential risks and benefits of combining these medications. A more recent study from 2019 3 discusses the efficacy and safety of oral combination therapies for erectile dysfunction when PDE5 inhibitor monotherapy fails, but it does not specifically address the combination of vardenafil and doxepin.
If you need to take both medications, it's crucial to consult your healthcare provider, who may adjust dosages, recommend taking them at different times, or monitor you more closely. They might also consider alternative medications that have fewer interaction concerns. Always inform all your healthcare providers about all medications you're taking, including over-the-counter drugs and supplements, to avoid potentially dangerous drug interactions.
Some key points to consider when taking vardenafil with doxepin include:
- Monitoring blood pressure and heart rhythm closely
- Adjusting dosages or timing of medication intake as needed
- Being aware of potential side effects, such as dizziness or lightheadedness
- Informing all healthcare providers about medication use, including supplements and over-the-counter drugs.