From the Guidelines
Insulin Type for IV Infusion
Short-acting insulin is used in an intravenous (IV) insulin infusion.
- The most commonly used short-acting insulin for IV infusion is human regular insulin 1, 2.
- The dose of short-acting insulin for IV infusion can be started at 0.05 units/kg/h and adjusted based on glycemic fluctuations and immediate past and current insulin infusion rates 1, 2.
- The use of short-acting insulin as a fixed-rate IV infusion or nurse-driven protocol with a variable rate based on glucose values is recommended for managing diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) 1, 2.
- There is no significant difference in outcomes for intravenous human regular insulin versus subcutaneous rapid-acting analogs when combined with aggressive fluid management for treating mild or moderate DKA 3.
From the FDA Drug Label
Intravenous administration of Humulin R U-100 is possible under medical supervision with close monitoring of blood glucose and potassium levels to avoid hypoglycemia and hypokalemia. For intravenous use, Humulin R U-100 should be used at concentrations from 0.1 unit/mL to 1 unit/mL in infusion systems with the infusion fluids 0.9% sodium chloride using polyvinyl chloride infusion bags.
The type of insulin used in an intravenous (IV) insulin infusion is Humulin R U-100, which is a short-acting insulin 4.
From the Research
Type of Insulin Used in IV Infusion
- The type of insulin used in an intravenous (IV) insulin infusion is typically regular insulin, which is a short-acting insulin 5, 6.
- Regular insulin is often used in IV infusions because of its rapid onset of action and short duration of effect, making it easier to control blood glucose levels 5.
- The use of regular insulin in IV infusions is supported by studies that have shown its effectiveness in managing hyperglycemia in various clinical settings, including emergency departments and non-intensive care units 5, 7, 6.
Administration of IV Insulin Infusion
- IV insulin infusions can be administered using different regimens, including bolus injections and continuous infusions 5.
- The choice of regimen depends on the clinical context and the patient's individual needs, such as the severity of hyperglycemia and the presence of other medical conditions 5, 7.
- Studies have shown that IV insulin infusions can be safely and effectively administered in non-intensive care units, with careful monitoring of blood glucose levels and adjustment of the infusion rate as needed 7.
Safety and Efficacy of IV Insulin Infusion
- IV insulin infusions have been shown to be effective in reducing blood glucose levels and improving glycemic control in patients with hyperglycemia 5, 7, 6.
- However, IV insulin infusions can also be associated with potential risks, such as hypoglycemia and hypokalemia, which require careful monitoring and management 5, 6.
- Studies have highlighted the importance of careful patient selection, monitoring, and adjustment of the infusion rate to minimize the risks associated with IV insulin infusions 7, 6.