Are recurrent toenail avulsions (nail separations) a sign of underlying issues, such as onychomycosis (fungal infection of the nail) or other systemic conditions?

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From the Guidelines

Recurrent toenail avulsions are a sign of underlying issues, such as fungal infections, trauma, or systemic diseases, which require prompt attention to prevent complications and improve quality of life. The most recent and highest quality study 1 provides guidance on the prevention and management of dermatological toxicities, including paronychia, which can lead to toenail avulsions. According to this study, gentle skin care, proper footwear, and avoidance of trauma can help prevent toenail avulsions.

Causes of Recurrent Toenail Avulsions

  • Fungal infections (onychomycosis), which can be treated with oral antifungals like terbinafine or topical solutions like ciclopirox nail lacquer 1
  • Trauma from ill-fitting shoes or repetitive pressure, necessitating proper footwear with adequate toe box space
  • Ingrown toenails, which may require partial nail plate removal with phenolization to prevent recurrence
  • Underlying peripheral vascular disease or diabetes, which can compromise circulation and healing, requiring medical management of these conditions

Management of Recurrent Toenail Avulsions

  • Proper nail care, including keeping nails trimmed straight across, avoiding cutting too short, wearing appropriate footwear, and maintaining good foot hygiene
  • Topical treatments, such as povidone iodine 2% or topical antibiotics and corticosteroids, for mild cases of paronychia 1
  • Oral antibiotics or surgical intervention for more severe cases of paronychia or toenail avulsions
  • Consultation with a podiatrist or dermatologist for prompt evaluation and treatment to prevent complications and address the root cause effectively.

From the Research

Recurrent Toenail Avulsions

Recurrent toenail avulsions can be a sign of underlying issues, including:

  • Viral infections
  • Autoimmune disorders
  • Drug side effects
  • Physical trauma 2
  • Onychomycosis, a fungal infection of the toenails, which can cause pain and discomfort 3
  • Ingrown toenails, which can be associated with granulation tissue and may require surgical treatment 4, 5

Possible Causes

Some possible causes of recurrent toenail avulsions include:

  • Microtrauma associated with footwear 2
  • Poor nail care or hygiene
  • Abnormal nail growth or shape
  • Systemic diseases, such as diabetes or peripheral artery disease

Treatment Options

Treatment options for recurrent toenail avulsions may include:

  • Topical creams or ointments, such as urea 40% cream 2
  • Oral antifungal medications for onychomycosis 3
  • Surgical procedures, such as partial nail avulsion or matricectomy 4, 5
  • Nonoperative treatment, such as nail care advice and topical antibiotics, which may be recommended for children and adolescents 6

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Ciclopirox nail lacquer topical solution 8% in the treatment of toenail onychomycosis.

Journal of the American Academy of Dermatology, 2000

Research

A New Perspective on Partial Nail Avulsion: Surgical Pearl.

Journal of cutaneous and aesthetic surgery, 2023

Research

Treatment of recurrent ingrown great toenail associated with granulation tissue by partial nail avulsion followed by matricectomy with sharpulse carbon dioxide laser.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2002

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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