Can povidone-iodine (Betadine) relieve pharyngitis?

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Last updated: May 21, 2025View editorial policy

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From the Guidelines

Betadine can help relieve sore throat symptoms temporarily, and its use is supported by the most recent evidence from 2020 1. The product typically comes as gargles or throat sprays containing 0.5-1% povidone-iodine and works by killing bacteria and viruses that may cause throat infections. For adults and children over 6 years, gargle or spray as directed on the package, usually 4-6 times daily for no more than 7 days. To use the gargle, dilute if required per instructions, gargle for 30 seconds, then spit out - do not swallow. For the spray, apply directly to the throat as directed. Betadine works through its broad-spectrum antimicrobial properties, reducing the microbial load in the throat and potentially decreasing inflammation. Some key points to consider when using Betadine for sore throat relief include:

  • The product is not a cure for bacterial infections requiring antibiotics
  • If sore throat persists beyond 2-3 days, is severe, or is accompanied by high fever or difficulty swallowing, consult a healthcare provider
  • People allergic to iodine should avoid these products, and they're not recommended for pregnant women or those with thyroid disorders
  • The use of Betadine for sore throat relief is supported by recent evidence, but it is essential to follow the instructions and take necessary precautions to avoid any potential side effects. It's also important to note that while Betadine can provide temporary relief, other treatments such as analgesics and throat lozenges may also be effective in reducing pain and discomfort associated with sore throat, as suggested by other studies 1.

From the Research

Betadine and Sore Throat Relief

  • There is no direct evidence in the provided studies that Betadine can relieve a sore throat 2, 3, 4, 5.
  • However, one study discusses the use of povidone-iodine (Betadine) in the treatment of chronic wounds, including its effectiveness in preventing the progression of superficial skin ulcers 6.
  • This study suggests that Betadine can be effective in reducing bacterial colonization and promoting wound healing, but it does not specifically address its use in relieving sore throats.
  • The other studies focus on the treatment of pharyngitis, the common cold, and acute pain, but do not mention Betadine as a treatment option for sore throats 2, 3, 4, 5.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) and acetaminophen are recommended for relieving pain associated with pharyngitis and other conditions, but Betadine is not mentioned as a treatment for sore throat 2, 3, 5.

References

Guideline

Guideline Directed Topic Overview

Dr.Oracle Medical Advisory Board & Editors, 2025

Research

Pharyngitis.

Primary care, 2014

Research

Pharyngitis: Approach to diagnosis and treatment.

Canadian family physician Medecin de famille canadien, 2020

Research

Treatment of the Common Cold.

American family physician, 2019

Research

Pharmacologic Therapy for Acute Pain.

American family physician, 2021

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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