Can the Liletta (levonorgestrel) intrauterine device (IUD) cause hair loss?

From the Guidelines

Hormonal IUDs like Liletta can potentially cause hair loss in some users due to the progestin hormone levonorgestrel, which can increase the effect of androgens in the body and trigger hair thinning. This side effect is relatively uncommon but does occur in a small percentage of women. Liletta releases a low dose of levonorgestrel locally in the uterus, but small amounts do enter the bloodstream and can affect hormone balance throughout the body 1. Some key points to consider:

• Hair loss may occur because progestins can increase the effect of androgens (male hormones) in the body, which can trigger hair thinning in women who are sensitive to these hormonal changes or who have a genetic predisposition to hormone-related hair loss.
• If you're experiencing hair loss while using Liletta, it's essential to consult with your healthcare provider to evaluate whether the IUD is likely the cause or if other factors might be contributing.
• In some cases, the hair loss may be temporary and resolve on its own as your body adjusts to the hormones.
• For persistent or concerning hair loss, your provider might recommend alternative contraceptive methods with different hormonal profiles or non-hormonal options 2. It's crucial to weigh the benefits and risks of using Liletta or any other hormonal IUD, considering individual factors and medical history, to make an informed decision about the best contraceptive method.

From the Research

Progesterone IUD and Hair Loss

• The relationship between progesterone IUDs, such as Liletta, and hair loss is not directly addressed in the provided studies.
• However, a study on the levonorgestrel intrauterine device (IUD) found that it can cause hair loss, with an estimated cumulative incidence of alopecia of 0.33% 3.
• Another study compared the Mirena and Liletta levonorgestrel IUDs for the treatment of endometrial intraepithelial neoplasia and grade 1 endometrioid endometrial cancer, but did not mention hair loss as a side effect 4.
• The other studies provided focus on the use of levonorgestrel IUDs for various gynecological conditions, but do not discuss hair loss 5, 6, 7.

Mechanism of Hair Loss

• The exact mechanism of hair loss associated with progesterone IUDs is not clear, but it may be related to the hormonal changes caused by the device 3.
• Progesterone can affect hair growth, and changes in progesterone levels may contribute to hair loss 3.

Conclusion Not Applicable

Instead, Further Research

• Further research is needed to determine the relationship between progesterone IUDs, such as Liletta, and hair loss.
• Studies should investigate the incidence and mechanisms of hair loss associated with these devices to provide more information for patients and healthcare providers 3, 4.