What is the efficacy of the Novibac (Lyme disease vaccine) in dogs?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 21, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

From the Research

The Novibac Lyme vaccine is a highly effective option for protecting dogs against Lyme disease, and the most recent evidence suggests that a basic vaccination schedule with an additional booster vaccination on day 180 provides the best possible protection 1. To determine the effectiveness of the Novibac Lyme vaccine, it's essential to consider the most recent and highest-quality studies.

Key Findings

  • A retrospective study published in 2022 found that dogs vaccinated with the standard vaccination schedule displayed decreasing antibody levels between days 120 and 360, which is probably insufficient to prevent an infection with borreliae 1.
  • The same study found that an additional booster vaccination on day 180 intercepts this decline in antibody levels between days 225 and 360, providing a sufficient immunity to prevent infection 1.

Vaccination Schedule

  • The recommended vaccination schedule for the Novibac Lyme vaccine is two doses administered 2-3 weeks apart, followed by annual boosters to maintain protection.
  • Puppies can typically start the vaccine series at 12 weeks of age.

Side Effects and Precautions

  • Side effects are generally mild and may include temporary soreness at the injection site, mild fever, or lethargy for 1-2 days after administration.
  • The vaccine is particularly recommended for dogs living in or traveling to areas with high tick populations or where Lyme disease is endemic.

Comprehensive Tick Prevention Strategy

  • While vaccination is important, it should be part of a comprehensive tick prevention strategy that includes regular tick checks, prompt tick removal, and appropriate tick preventatives.
  • Not all dogs require this vaccine, so consult with your veterinarian to determine if Novibac Lyme vaccine is appropriate for your dog based on geographic location, lifestyle, and risk factors.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.