Differential Diagnosis for Pearl-looking Growth near Lateral Canthus of the Eye
- Single most likely diagnosis
- Basal cell carcinoma: This is the most common type of skin cancer and can present as a pearly nodule, often found on the face, including near the eyes. Its appearance near the lateral canthus, coupled with its pearl-like appearance, makes it a prime suspect.
- Other Likely diagnoses
- Squamous cell carcinoma: Although less common than basal cell carcinoma, squamous cell carcinoma can also appear as a nodule and may have a pearly appearance, especially in its early stages.
- Keratoacanthoma: This is a low-grade malignancy that can resemble squamous cell carcinoma and may present as a firm, round, skin-colored to pearl-colored nodule.
- Sebaceous gland hyperplasia: Benign growths of the sebaceous glands can appear as yellowish or pearl-like papules, especially on the face.
- Do Not Miss (ddxs that may not be likely, but would be deadly if missed.)
- Malignant melanoma: Although less likely to present as a pearl-looking growth, melanoma can have varied appearances, including amelanotic forms that might resemble a pearly nodule. Missing this diagnosis could be fatal due to melanoma's potential for aggressive behavior and metastasis.
- Adnexal gland tumors (e.g., sebaceous carcinoma): These are rare but can be aggressive. Sebaceous carcinoma, in particular, can mimic benign conditions but has a high potential for metastasis if not treated early.
- Rare diagnoses
- Trichoepithelioma: A rare, benign tumor of hair follicle origin that can appear as a small, pearly nodule.
- Syringoma: Benign tumors of eccrine sweat gland origin, which can present as multiple small, skin-colored or pearl-like papules, often around the eyes.
- Microcystic adnexal carcinoma: A rare, malignant tumor that can appear as a firm, flesh-colored to pearl-like nodule, often with a tendency to invade deeply and recur locally.