From the Research
The use of micronized progesterone for treating uterine fibroids is not recommended due to lack of evidence of its efficacy, as suggested by the most recent review in 2020 1. Instead, alternative treatments such as mifepristone, a progesterone antagonist, have shown promise in reducing fibroid size and symptoms, as demonstrated in a study published in 2016 2. The typical dose of mifepristone for treating uterine fibroids is 50 mg taken orally once a week for 6 months. To use:
- Take the tablets orally with water
- Use consistently every week for best results
- Continue for the full prescribed duration, even if symptoms improve earlier Mifepristone works by blocking the effects of progesterone on fibroid tissue, potentially reducing heavy menstrual bleeding associated with fibroids. Side effects may include transient changes in liver function tests, but these are usually reversible after stopping treatment. Regular follow-ups are important to monitor fibroid size and symptoms. It is essential to note that the treatment of uterine fibroids should be individualized, and the choice of therapy should be based on the patient's specific needs and medical history, as well as the latest available evidence 1, 2.