What is the differential diagnosis (DDX) of hemoptysis?

Medical Advisory BoardAll articles are reviewed for accuracy by our Medical Advisory Board
Educational purpose only • Exercise caution as content is pending human review
Article Review Status
Submitted
Under Review
Approved

Last updated: May 21, 2025View editorial policy

Personalize

Help us tailor your experience

Which best describes you? Your choice helps us use language that's most understandable for you.

Differential Diagnosis for Hemoptysis

Single Most Likely Diagnosis

  • Chronic Bronchitis: This is often the most common cause of hemoptysis, especially in smokers, due to the chronic inflammation and damage to the airways.

Other Likely Diagnoses

  • Pneumonia: Bacterial, viral, or fungal infections can cause hemoptysis, especially if they lead to lung abscesses or cavitation.
  • Bronchiectasis: A condition characterized by damaged, dilated airways, often due to recurrent infections, which can lead to chronic hemoptysis.
  • Lung Cancer: Both primary and metastatic lung cancers can cause hemoptysis, especially if they invade or erode into airways.
  • Tuberculosis: Although less common in some regions, TB remains a significant cause of hemoptysis worldwide, particularly in areas with high prevalence.

Do Not Miss Diagnoses

  • Pulmonary Embolism: Although less common as a cause of hemoptysis, it is critical to consider due to its high mortality rate if not promptly treated.
  • Aortic Aneurysm or Aortobronchial Fistula: These conditions can cause massive, life-threatening hemoptysis and must be ruled out, especially in patients with risk factors for vascular disease.
  • Goodpasture Syndrome: An autoimmune disease that can cause rapidly progressive glomerulonephritis and pulmonary hemorrhage, including hemoptysis.

Rare Diagnoses

  • Mitral Stenosis: Can lead to hemoptysis due to pulmonary venous hypertension and subsequent hemorrhage.
  • Wegener's Granulomatosis (Granulomatosis with Polyangiitis): A form of vasculitis that can affect the lungs and kidneys, causing hemoptysis among other symptoms.
  • Pulmonary Arteriovenous Malformations: Congenital or acquired abnormalities that can cause hemoptysis, often associated with hereditary hemorrhagic telangiectasia.
  • Aspergilloma: A fungal infection that can cause hemoptysis, particularly in immunocompromised patients or those with pre-existing lung disease.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

Have a follow-up question?

Our Medical A.I. is used by practicing medical doctors at top research institutions around the world. Ask any follow up question and get world-class guideline-backed answers instantly.