From the Guidelines
Diane should consult with her doctor to determine the best course of treatment for her specific medical condition, as the use of any medication, including Diane-35, should be based on a thorough evaluation of her health history, age, weight, allergies, and potential drug interactions. According to a recent study published in 2024 1, Diane-35, which contains 2-mg cyproterone acetate and 35-μg ethinylestradiol, has been used in the treatment of polycystic ovary syndrome (PCOS) and acne. However, the study highlights the importance of considering the potential risks and benefits of any medication, including the risk of venous thromboembolic events (VTE) and cardiovascular disease.
- The study found that COCs, including Diane-35, can reduce acne lesions and improve hormonal and metabolic outcomes in women with PCOS.
- However, the study also notes that the use of COCs is associated with an increased risk of VTE and cardiovascular disease, particularly in women who smoke or have a history of hypertension or diabetes.
- Another study published in 2016 1 found that COCs, including those containing drospirenone, can increase the risk of VTE and cardiovascular disease, but the absolute risk remains low in healthy women.
- A more recent study published in 2023 1 reviewed the current evidence on the use of oral contraceptive pills (OCPs) and hypertension, and found that while OCPs can increase blood pressure, the risk of hypertension and cardiovascular disease can be minimized by using low-dose estrogen and progestin-only pills.
In light of these findings, it is essential for Diane to consult with her doctor to determine the best course of treatment for her specific medical condition, taking into account her individual risk factors and health history. The doctor can assess her symptoms, make a proper diagnosis, and prescribe appropriate treatment, considering factors such as her age, weight, allergies, and potential drug interactions. Self-medication or taking medication based on general advice without proper medical evaluation can be dangerous and lead to adverse effects. If Diane is experiencing a medical emergency, she should seek immediate medical attention rather than looking for medication advice online.
From the Research
Diane Medication Overview
- Diane medication is a combination of cyproterone acetate and ethinyl estradiol, used to treat conditions such as hirsutism, acne, and alopecia 2, 3, 4.
- The medication has been shown to be effective in reducing symptoms of hyperandrogenism, with success rates of 94% for acne, 85% for hirsutism, and 55% for alopecia 2.
Effects on Androgen Levels
- Studies have found that Diane medication decreases free testosterone levels and 5 alpha-androstane-3 alpha, 17 beta-diol-glucuronide, a parameter of peripheral androgen formation 3.
- The medication also decreases dehydroepiandrosterone sulfate levels, and increases sex hormone-binding globulin (SHBG) levels 3.
Comparison with Other Treatments
- A study compared the effects of Diane 35 (cyproterone acetate 2 mg and ethinylestradiol 35 micrograms per pill) with Diane 50 (cyproterone acetate 2 mg and ethinylestradiol 50 micrograms per pill) on plasma androgens and lipids, and found that both drugs were effective in treating acne and hirsutism, but Diane 35 had a more favorable effect on lipid profiles 3.
Prescribing Patterns and Risks
- The use of Diane medication has increased over the years, particularly among women with acne or polycystic ovary syndrome (PCOS) 5.
- However, concerns have been raised about the long-term use of Diane medication due to the risk of venous thromboembolism, although some studies suggest that the risks are no more common than with the use of third-generation combined oral contraceptives 6.