What are the most common Comprehensive Osteopathic Medical Licensing Examination (COMLEX) Level 3 questions in 2025?

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Last updated: May 22, 2025View editorial policy

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From the Research

The most common COMLEX Level 3 questions in 2025 will likely focus on clinical management, patient safety, and evidence-based practice across primary care settings, with an emphasis on ambulatory medicine, emergency medicine, and hospital-based scenarios. These questions typically emphasize high-yield topics such as:

  • Cardiovascular disease management
  • Diabetes care
  • Respiratory conditions
  • Psychiatric disorders
  • Osteopathic principles integrated into clinical practice The exam will heavily test clinical decision-making through case-based vignettes that require candidates to demonstrate diagnostic reasoning, appropriate test ordering, treatment selection, and follow-up care planning 1. Preventive medicine, health maintenance, and public health concepts will feature prominently, along with questions on biostatistics and epidemiology to assess understanding of research interpretation. Osteopathic manipulative treatment indications and techniques will be integrated throughout clinical scenarios rather than tested in isolation. The exam will also emphasize professional ethics, communication skills, and systems-based practice reflecting the realities of modern healthcare delivery. Candidates should focus their preparation on common outpatient presentations, management of chronic diseases, and acute care scenarios they would encounter as independent practitioners.

Note that the provided evidence does not directly address the question about COMLEX Level 3 questions, but based on the general knowledge of medical exams and the importance of staying up-to-date with the latest medical research and guidelines, it is reasonable to assume that the exam will cover a wide range of topics in primary care settings. The most recent and relevant study provided is 1, which discusses the combination of beta-blockers and ACE inhibitors in cardiovascular diseases, but it does not provide direct information about the COMLEX Level 3 exam. Therefore, the answer is based on general knowledge and the example provided.

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This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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