What is the cause of chest pain (thoracic pain)?

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Last updated: May 22, 2025View editorial policy

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Differential Diagnosis for Chest Pain

The differential diagnosis for chest pain is extensive and can be categorized into several groups. Here's a breakdown of the possible causes:

  • Single Most Likely Diagnosis

    • Acute Coronary Syndrome (ACS): This is the most common cause of chest pain in adults, particularly those with risk factors such as hypertension, diabetes, and high cholesterol. The pain is typically described as a pressure or heaviness in the chest that may radiate to the arms, neck, or jaw.
  • Other Likely Diagnoses

    • Gastroesophageal Reflux Disease (GERD): Chest pain can be a symptom of GERD, especially if it's accompanied by regurgitation, dysphagia, or a sour taste in the mouth.
    • Musculoskeletal Pain: Costochondritis, muscle strain, or rib fractures can cause chest pain that's often sharp and localized to a specific area.
    • Pulmonary Embolism (PE): While not as common as ACS, PE is a significant cause of chest pain, especially in patients with risk factors such as deep vein thrombosis, cancer, or recent surgery.
    • Pneumonia: Chest pain can be a symptom of pneumonia, especially if it's accompanied by fever, cough, or shortness of breath.
  • Do Not Miss Diagnoses

    • Aortic Dissection: A life-threatening condition that requires immediate attention, aortic dissection can cause severe, tearing chest pain that radiates to the back.
    • Pulmonary Embolism (PE): As mentioned earlier, PE is a significant cause of chest pain and can be fatal if not treated promptly.
    • Cardiac Tamponade: A condition where fluid accumulates in the pericardial sac, cardiac tamponade can cause chest pain, shortness of breath, and hypotension.
    • Esophageal Rupture: A rare but life-threatening condition, esophageal rupture can cause severe chest pain, vomiting, and difficulty swallowing.
  • Rare Diagnoses

    • Pericarditis: Inflammation of the pericardium can cause chest pain that's often sharp and stabbing.
    • Pneumothorax: A collapsed lung can cause chest pain, shortness of breath, and decreased lung sounds on the affected side.
    • Mitral Valve Prolapse: A condition where the mitral valve doesn't close properly, mitral valve prolapse can cause chest pain, palpitations, and shortness of breath.
    • Thoracic Aortic Aneurysm: A rare condition where the aorta dilates, thoracic aortic aneurysm can cause chest pain, back pain, and shortness of breath.

Professional Medical Disclaimer

This information is intended for healthcare professionals. Any medical decision-making should rely on clinical judgment and independently verified information. The content provided herein does not replace professional discretion and should be considered supplementary to established clinical guidelines. Healthcare providers should verify all information against primary literature and current practice standards before application in patient care. Dr.Oracle assumes no liability for clinical decisions based on this content.

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