From the Research
Chronic inflammation is a contributing factor to degenerative disc disease, but it is not the sole cause, and its role is complex, involving the interplay of various factors including age, genetics, and mechanical stress, as suggested by the most recent study 1. The process of degenerative disc disease involves:
- Reduced nutrient supply to the disc due to endplate degeneration
- Accumulation of waste products in the disc
- Acidic environment in the disc
- Disc dehydration and weakening
- Increased vulnerability to rupture Chronic inflammation plays a role in this process, but its connection to brain inflammation and spinal muscle function, such as the multifidus muscle, is less established 2, 3. To maintain spine health, it is recommended to:
- Engage in regular exercise, especially core-strengthening
- Practice proper posture and ergonomics
- Maintain a healthy weight
- Avoid smoking
- Stay hydrated If experiencing back pain, it is essential to consult a healthcare provider for a proper diagnosis and treatment plan, which may include physical therapy, anti-inflammatory medications, or in severe cases, surgical intervention 4. The role of inflammatory mediators, such as nitric oxide, interleukins, and tumor necrosis factor alpha, in intervertebral disc degeneration has been implicated in several studies 5, 4, highlighting the complexity of the disease process. Overall, while chronic inflammation is a contributing factor to degenerative disc disease, a comprehensive approach to maintaining spine health and managing back pain is necessary, taking into account the interplay of various factors and the latest evidence from studies such as 1.